Journal Publication

 

2020年

  Non-clinical combination toxicology studies: strategy, examples and future perspective
J Toxicol Sci. 2020;45(7):365-371
  Abstract                       Full Text
 

2019年

  Current Status and Future Perspective of Computational Toxicology in Drug Safety Assessment Under Ontological Intellection
J Toxicol Sci. 2019;44(11):721-735
  Abstract                       Full Text
  Safety biomarker applications in drug development.
J Toxicol Sci. 2019;44(4):225-235.
  Abstract                       Full Text
 

2016年

  The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science? -
J Toxicol Sci. 2016;41(Special Issue):SP49-SP67.
  Abstract                       Full Text
 

2013年

  Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta.
J Toxicol Sci. 2013;38(1):159-67.
  Abstract                       Full Text
 

2012年

  6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta.
J Toxicol Sci. 2012;37(3):607-15.
  Abstract                       Full Text
  AP2 mediates BSEP internalization and modulates its hepatocanalicular expression and transport function.
Hepatology. 2012 Jun;55(6):1889-900.
  Abstract                       Full Text
 

2011年

  MicroRNAs expression in the ethylene glycol monomethyl ether-induced testicular lesion
J Toxicol. Sci. 2011 Oct;36(5):601-11
  Abstract                       Full Text
 

2010年

  医薬品の早期開発戦略とメディシナルケミスト
-医薬品の早期開発における安全性評価研究者と医薬品合成化学者との関わり-
Medchem News 2010 Aug;20(3):11-4
  Abstract                       Full Text
  医薬品の毒作用発現とその評価 ダーウィン毒性学的思考への歩み
ファルマシア 2010 Aug;46(8):765-9
  Abstract                       Full Text
  Toxic effect onset and evaluations of medicinal drugs - horizon for Darwinian toxicological thought -
J Toxicol Sci. 2010 Aug;35(4):425-35
  Abstract                       Full Text
 

2008年

  Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen
Toxicol Pathol. 2008;36(4):581-91.
  Abstract                       Full Text
  In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes
J Appl Toxicol. 2008 Mar;28(2):227-36.
  Abstract                       Full Text
  In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells.
J Appl Toxicol. 2008 Mar;28(2):237-48
  Abstract                       Full Text
  Aging-related changes of QT and RR intervals in conscious guinea pigs.
J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):23-9.
  Abstract                       Full Text
 

2007年

  Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats
J Toxicol Sci. 2007 Dec;32(5):515-28
  Abstract                       Full Text
  Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride--regulating role of micro-RNA for RNA expression.
J Toxicol Sci. 2007 Oct;32(4):401-9.
  Abstract                       Full Text
  Effect of dose regimen on the toxicity of 2'-deoxy-2'-methylidenecytidine (DMDC) in monkeys.
J Toxicol Sci. 2007 Oct;32(4):343-57.
  Abstract                       Full Text
  In vitro hepatotoxicity testing in the early phase of drug discovery.
AATEXi
. 2007 Aug;14(S):437-441
  Abstract                       Full Text
  Simultaneous measurement of nucleated cell counts and cellular differentials in rat bone marrow examination using flow cytometer.
J Toxicol Sci
. 2007 Aug;32(3):289-299
  Abstract                       Full Text
  Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches--effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine. J Toxicol Sci. 2007 Aug;32(3):205-215
  Abstract                       Full text
  Principles of general toxicology for practical safety assessment
一般毒性試験(単回投与毒性・反復投与毒性)─実践的な毒性評価に向けて─
Nippon Yakurigaku Zasshi. 2007 Jun;129(6):463-467.
  Abstract                       Full text
  Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine.
Reprod Toxicol. 2007 Feb;23(2):153-157.
  Abstract                       Full text
 

2006年

  Genomic cluster and network analysis for predictive screening for hepatotoxicity.
J Toxicol Sci. 2006 Dec;31(5):419-32.
  Abstract                       Full text
  Clinical toxicology and metabonomics
Chudoku Kenkyu. 2006 Oct;19(4):373-81.
  Abstract                       Full text
  Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential.
J Toxicol Sci. 2006 Oct;31(4):315-24.
  Abstract                       Full text
  Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
J Toxicol Sci. 2006 Aug;31(3):265-85.
  Abstract                       Full text
  Methodological validation of an existing telemetry system for QT evaluation in conscious guinea pigs.
J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):27-34.
  Abstract                       Full text
  Safety, pharmacokinetic, and physicochemical studies in the early stage of drug discovery
新薬の創出に重要な創薬初期段階での安全性,薬物動態および物性試験
Nippon Yakurigaku Zasshi. 2006 Mar;127(3):217-21.
  Abstract                       Full text
  Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants.
J Toxicol Sci. 2006 Feb;31(1):49-60.
  Abstract                       Full text
  In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system.
J Toxicol Sci. 2006 Feb;31(1):23-34.
  Abstract                       Full text
  トキシコゲノミクスの応用:医薬品安全性評価における毒性学的バイオマーカーの現状と将来展望(最前線,<特集>○○ミクス:医薬品のパラダイムシフト)
ファルマシア, 2006; 42(1): 37-41
  Abstract                       Full text
 

2005年

  Cisplatin-induced cytotoxicity in BSO-exposed renal proximal tubular epithelial cells: sex, age, and species.
Ren Fail. 2005;27(5):629-33.
  Abstract                       Full text
  Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
J Toxicol Sci. 2005; 30 (Suppl.): pp.S165
  Abstract                       Full text
  トキシコゲノミクスと薬剤感受性
最新医学, 2005; 60: 1841-1851
  Abstract                       Full text
  Practical application of guinea pig telemetry system for QT evaluation.
J Toxicol Sci. 2005 Aug;30(3):239-47.
  Abstract                       Full text
  Effect of autonomic nervous function on QT interval in dogs.
J Toxicol Sci. 2005 Aug;30(3):229-37.
  Abstract                       Full text
  Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach.
J Toxicol Sci. 2005 Aug;30(3):213-27.
  Abstract                       Full text
  Effects of male reproductive toxicants on gene expression in rat testes.
J Toxicol Sci. 2005 Aug;30(3):195-206.
  Abstract                       Full text
  Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.
J Toxicol Sci. 2005 May;30(2):111-26.
  Abstract                       Full text
  Investigation of a hepatotoxicity screening system in primary cell cultures --"what biomarkers would need to be addressed to estimate toxicity in conventional and new approaches?".
J Toxicol Sci. 2005 Feb;30(1):61-72.
  Abstract                       Full text
  Effects of sulfasalazine on sperm acrosome reaction and gene expression in the male reproductive organs of rats.
Toxicol Sci. 2005 May;85(1):675-82.
  Abstract                       Full text
 

2004年

  Effects of BSO and L-cysteine on drug-induced cytotoxicity in primary cell cultures: drug-, cell type-, and species-specific difference.
Drug Chem Toxicol. 2004 Aug;27(3):269-80.
  Abstract                       Full text
  Blood coagulation tests in toxicological studies--review of methods and their significance for drug safety assessment.
J Toxicol Sci. 2004 Feb;29(1):13-32.
  Abstract                       Full text
  Mechanism for shortening PT and APTT in dogs and rats--effect of fibrinogen on PT and APTT--.
J Toxicol Sci. 2003 Dec;28(5):439-43.
  Abstract                       Full text
  In vitro and in vivo assays for high-molecular-weight pegylated muteins of granulocyte colony-stimulating factor.
Methods Mol Biol. 2004;249:167-76
  Abstract                       Full text
  Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
  Abstract                       Full text
  [Clinical toxicology and toxicogenomics]
Chudoku Kenkyu. 2002 Jul;15(3):263-9
  Abstract                       Full text
  Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines.
J Toxicol Sci. 2002 Aug;27(3):229-37.
  Abstract                       Full text
  Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors.
J Chem Inf Comput Sci. 2002 Jul-Aug;42(4):968-75.
  Abstract                       Full text
  5-Fluorouracil-induced intestinal toxicity: what determines the severity of damage to murine intestinal crypt epithelia?
Toxicol Lett. 2002 Jul 21;133(2-3):231-40.
  Abstract                       Full text
  Assessment of quantitative dual-parameter flow cytometric analysis for the evaluation of testicular toxicity using cyclophosphamide- and ethinylestradiol-treated rats.
J Toxicol Sci. 2002 May;27(2):87-96.
  Abstract                       Full text
   
  Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice.
J Toxicol Sci. 2002;27(2):79-86
  Abstract                       Full text
   
  Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine.
J Toxicol Sci. 2002;27(2):123-30.
  Abstract                       Full text
  Comparative toxicological assessment of a water-soluble azole administered both orally and by intravenous continuous infusion in cynomolgus monkeys.
J Toxicol Sci. 2002;27(2):107-22.
  Abstract                       Full text
  Endocrinological assessment of toxic effects on the male reproductive system in rats treated with 5-fluorouracil for 2 or 4 weeks.
J Toxicol Sci. 2002;27(1):49-56
  Abstract                       Full text
  2003年
   
  2002年
  ADVANTAGES OF IN VITRO CYTOTOXICITY TESTING BY USING PRIMARY RAT HEPATOCYTES IN COMPARISON WITH ESTABLISHED CELL LINES
J. Toxicol. Sci., 2002; 27: 229-237
  Abstract                       Full text
  5-Fluorouracil-induced intestinal toxicity: what determines the severity of damage to murine intestinal crypt epithelia?
Toxicol. Letters, 2002; 133: 231-240
  Abstract                       Full text
  2001年
  A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU
Pharmaceut. Res., 2001; 18: 1190-1202
  Abstract                       Full text
  Synthesis and antifungal activities of novel 1,3-β-Image-glucan synthase inhibitors. Part 1
Bioorganic Med. Chem., 2001; 11: 395-398
  Abstract                       Full text
  2000年
  The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine
Bioorganic Med. Chem., 2000; 8: 1697-1706
  Abstract                       Full text
  1999年
  Discovery and Development of Novel Anticancer Drug Capecitabine
新規抗癌剤カタペシタビンの研究開発
薬学雑誌, 1999; 119: 881-897
  Abstract                       Full text
  Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein
Exp. hematol., 1999; 27: 425-432
  Abstract                       Full text
  1995年
  Flow cytometric analysis for the evaluation of the rat sperm viability and number in the male reproductive toxicity studies
Congenital Anomalies, 1995; 35(2): 177-187
  Abstract                       Full text
  1994年
  1992年
  EFFECT OF 1, 25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
J. Toxicol. Sci., 1992; 17: 91-105
  Abstract                       Full text
  1990年
  非特異的増殖性肉芽性炎症巣における脂質代謝に関する研究
  Abstract                       Full text
  1987年
  実験データの監査(<特集>監査と診断)
品質, 1987; 17(2): 44-48
  Abstract                       Full text
  1980年
  Procedures for renal function test in rats and their related problems: PSP excretion test and creatinine: clearance test
ラットに対する腎機能検査の実際とその問題点:PSP排泄試験,クレアチニン クリアランス試験
J. Toxicol. Sci., 1980; 5: 286-287
  Abstract                       Full text
  1979年
  アレルギー性炎症の病態機序:増殖性肉芽性炎症巣におおける脂質組成の変動とその意義
アレルギー, 1979; 28: 915
  Abstract                       Full text
  アレルギー性炎症における微小循環系の傷害機序(その1)(Chemical mediatorsおよび類似物質)
アレルギー, 1979; 28: 173-174
  Abstract                       Full text
  1976年
  病的条件下における結合組織由来のbiologically active cleavage products (Chemical mediators)
アレルギー, 1976; 25(4): 369-370
  Abstract                       Full text