Journal Publication
　

2021年
　 Microphysiological systems in early stage drug development: Perspectives on current applications and future impact
J Toxicol Sci. 2021;46(3):46-99
　 Abstract                       Full Text
　

2020年
　 Non-clinical combination toxicology studies: strategy, examples and future perspective
J Toxicol Sci. 2020;45(7):365-371
　 Abstract                       Full Text
　

2019年
　 Current Status and Future Perspective of Computational Toxicology in Drug Safety Assessment Under Ontological Intellection
J Toxicol Sci. 2019;44(11):721-735
　 Abstract                       Full Text
　 Safety biomarker applications in drug development.
J Toxicol Sci. 2019;44(4):225-235.
　 Abstract                       Full Text
　

2017年
　 毒性学の原点と医薬品安全性評価との接点からの進化毒性学への道
HAB News Letter, 2017;23(2):19-21.
　 Abstract                       Full Text
　

2016年
　 The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science? -
J Toxicol Sci. 2016;41(Special Issue):SP49-SP67.
　 Abstract                       Full Text
　 創薬に向けたヒト細胞・組織の利用 : Precision Medicineへの展開
レギュラトリーサイエンス学会誌 2016;6(1):71-9.
　 Abstract                       Full Text
　

2014年
　 薬物性催不整脈作用の統合的リスク予測
心電図. 2014;34(3):334-7.
　 Abstract                       Full Text
　

2013年
　 Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta.
J Toxicol Sci. 2013;38(1):159-67.
　 Abstract                       Full Text
　

2012年
　 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta.
J Toxicol Sci. 2012;37(3):607-15.
　 Abstract                       Full Text
　 AP2 mediates BSEP internalization and modulates its hepatocanalicular expression and transport function.
Hepatology. 2012 Jun;55(6):1889-900.
　 Abstract                       Full Text
　

2011年
　 MicroRNAs expression in the ethylene glycol monomethyl ether-induced testicular lesion
J Toxicol. Sci. 2011 Oct;36(5):601-11
　 Abstract                       Full Text
　

2010年
　 医薬品の早期開発戦略とメディシナルケミスト
-医薬品の早期開発における安全性評価研究者と医薬品合成化学者との関わり-
Medchem News 2010 Aug;20(3):11-4
　 Abstract                       Full Text
　 医薬品の毒作用発現とその評価 ダーウィン毒性学的思考への歩み
ファルマシア 2010 Aug;46(8):765-9
　 Abstract                       Full Text
　 Toxic effect onset and evaluations of medicinal drugs - horizon for Darwinian toxicological thought -
J Toxicol Sci. 2010 Aug;35(4):425-35
　 Abstract                       Full Text
　

2008年
　 Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen
Toxicol Pathol. 2008;36(4):581-91.
　 Abstract                       Full Text
　 In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes
J Appl Toxicol. 2008 Mar;28(2):227-36.
　 abstract                       Full Text
　 In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells.
J Appl Toxicol. 2008 Mar;28(2):237-48
　 abstract                       Full Text
　 Aging-related changes of QT and RR intervals in conscious guinea pigs.
J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):23-9.
　 abstract                       Full Text
　 Neuronal Necrosis in a Dog Following Exposure to an NMDA Receptor Antagonist
J. Toxicol. Pathol.21(3):185-8.
　 abstract                       Full Text
　

2007年
　 Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats
J Toxicol Sci. 2007 Dec;32(5):515-28
　 abstract                       Full Text
　 安全性の高い医薬品を創出するために(インタビュー, 特集，医薬品の副作用:副作用予測への挑戦)
ファルマシア，2007; 43(11):1059-62.
　 abstract                      Full Text
　 Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride--regulating role of micro-RNA for RNA expression.
J Toxicol Sci. 2007 Oct;32(4):401-9.
　 abstract                      Full Text
　 Effect of dose regimen on the toxicity of 2'-deoxy-2'-methylidenecytidine (DMDC) in monkeys.
J Toxicol Sci. 2007 Oct;32(4):343-57.
　 abstract                      Full Text
　 In vitro hepatotoxicity testing in the early phase of drug discovery.
AATEXi. 2007 Aug;14(S):437-441
　 Abstract                      Full Text
　 Simultaneous measurement of nucleated cell counts and cellular differentials in rat bone marrow examination using flow cytometer.
J Toxicol Sci. 2007 Aug;32(3):289-299
　 abstract                      Full Text
　 Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches--effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine. J Toxicol Sci. 2007 Aug;32(3):205-215
　 abstract                      Full text
　 Principles of general toxicology for practical safety assessment
一般毒性試験（単回投与毒性・反復投与毒性）─実践的な毒性評価に向けて─
Nippon Yakurigaku Zasshi. 2007 Jun;129(6):463-467.
　 abstract                      Full text
　 Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine.
Reprod Toxicol. 2007 Feb;23(2):153-157.
　 abstract                       Full text
　

2006年
　 Genomic cluster and network analysis for predictive screening for hepatotoxicity.
J Toxicol Sci. 2006 Dec;31(5):419-32.
　 abstract                      Full text
　 Clinical toxicology and metabonomics
Chudoku Kenkyu. 2006 Oct;19(4):373-81.
　 abstract                       Full text
　 Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential.
J Toxicol Sci. 2006 Oct;31(4):315-24.
　 abstract                      Full text
　 Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
J Toxicol Sci. 2006 Aug;31(3):265-85.
　 abstract                      Full text
　 Methodological validation of an existing telemetry system for QT evaluation in conscious guinea pigs.
J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):27-34.
　 abstract                       Full text
　 Safety, pharmacokinetic, and physicochemical studies in the early stage of drug discovery
新薬の創出に重要な創薬初期段階での安全性，薬物動態および物性試験
Nippon Yakurigaku Zasshi. 2006 Mar;127(3):217-21.
　 abstract                      Full text
　 Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants.
J Toxicol Sci. 2006 Feb;31(1):49-60.
　 abstract                      Full text
　 In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system.
J Toxicol Sci. 2006 Feb;31(1):23-34.
　 abstract                       Full text
　 トキシコゲノミクスの応用：医薬品安全性評価における毒性学的バイオマーカーの現状と将来展望(最前線，＜特集＞○○ミクス：医薬品のパラダイムシフト）
ファルマシア, 2006; 42(1): 37-41
　 abstract                       Full text
　

2005年
　 Cisplatin-induced cytotoxicity in BSO-exposed renal proximal tubular epithelial cells: sex, age, and species.
Ren Fail. 2005;27(5):629-33.
　 abstract                       Full text
　 Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
J Toxicol Sci. 2005; 30 (Suppl.): pp.S165
　 abstract                       Full text
　 トキシコゲノミクスと薬剤感受性
最新医学, 2005; 60: 1841-1851
　 Abstract（最新医学社、廃刊）                       Full text
　 Practical application of guinea pig telemetry system for QT evaluation.
J Toxicol Sci. 2005 Aug;30(3):239-47.
　 abstract                      Full text
　 Effect of autonomic nervous function on QT interval in dogs.
J Toxicol Sci. 2005 Aug;30(3):229-37.
　 abstract                      Full text
　 Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach.
J Toxicol Sci. 2005 Aug;30(3):213-27.
　 abstract                      Full text
　 Effects of male reproductive toxicants on gene expression in rat testes.
J Toxicol Sci. 2005 Aug;30(3):195-206.
　 abstract                      Full text
　 Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.
J Toxicol Sci. 2005 May;30(2):111-26.
　 abstract                      Full text
　 Investigation of a hepatotoxicity screening system in primary cell cultures --"what biomarkers would need to be addressed to estimate toxicity in conventional and new approaches?".
J Toxicol Sci. 2005 Feb;30(1):61-72.
　 abstract                      Full text
　 Effects of sulfasalazine on sperm acrosome reaction and gene expression in the male reproductive organs of rats.
Toxicol Sci. 2005 May;85(1):675-82.
　 abstract                       Full text
　

2004年
　 Effects of BSO and L-cysteine on drug-induced cytotoxicity in primary cell cultures: drug-, cell type-, and species-specific difference.
Drug Chem Toxicol. 2004 Aug;27(3):269-80.
　 abstract                       Full text<
/td>
　 Blood coagulation tests in toxicological studies--review of methods and their significance for drug safety assessment.
J Toxicol Sci. 2004 Feb;29(1):13-32.
　 abstract                      Full text
　 In vitro and in vivo assays for high-molecular-weight pegylated muteins of granulocyte colony-stimulating factor.
Methods Mol Biol. 2004;249:167-76
　 abstract                       Full text
　

2003年
　 Mechanism for shortening PT and APTT in dogs and rats--effect of fibrinogen on PT and APTT--.
J Toxicol Sci. 2003 Dec;28(5):439-43.
　 abstract                     Full text
　 医薬品安全性評価における分子毒性学的アプローチ-毒作用発現とトキシコゲノミクス・トキシコプロテオミクス・メタボロミクス-
学術の動向. 2003;8(9):76-7.
　 abstract                     Full text
　 Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Bio Med Chem Lett. 2003 Mar;13(5):867-72.
　 abstract                     Full text
　 2002年
　 [Clinical toxicology and toxicogenomics]
Chudoku Kenkyu. 2002 Jul;15(3):263-9
　 abstract                      Full text
　 Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors.
J Chem Inf Comput Sci. 2002 Jul-Aug;42(4):968-75.
　 abstract                      Full text
　 5-Fluorouracil-induced intestinal toxicity: what determines the severity of damage to murine intestinal crypt epithelia?
Toxicol Lett. 2002 Jul 21;133(2-3):231-40.
　 abstract                       Full text
　 Assessment of quantitative dual-parameter flow cytometric analysis for the evaluation of testicular toxicity using cyclophosphamide- and ethinylestradiol-treated rats.
J Toxicol Sci. 2002 May;27(2):87-96.
　 abstract                       Full text
　 Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice.
J Toxicol Sci. 2002;27(2):79-86
　 abstract                      Full text
　 Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine.
J Toxicol Sci. 2002;27(2):123-30.
　 abstract                      Full text
　 Comparative toxicological assessment of a water-soluble azole administered both orally and by intravenous continuous infusion in cynomolgus monkeys.
J Toxicol Sci. 2002;27(2):107-22.
　 Abstract                      Full text
　 Endocrinological assessment of toxic effects on the male reproductive system in rats treated with 5-fluorouracil for 2 or 4 weeks.
J Toxicol Sci. 2002;27(1):49-56
　 Abstract                      Full text
　 ADVANTAGES OF IN VITRO CYTOTOXICITY TESTING BY USING PRIMARY RAT HEPATOCYTES IN COMPARISON WITH ESTABLISHED CELL LINES
J. Toxicol. Sci., 2002; 27: 229-237
　 Abstract                       Full text
　 5-Fluorouracil-induced intestinal toxicity: what determines the severity of damage to murine intestinal crypt epithelia?
Toxicol. Letters, 2002; 133: 231-240
　 Abstract                       Full text
　 2001年
　 A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU
Pharmaceut. Res., 2001; 18: 1190-1202
　 Abstract                       Full text
　 経口抗癌剤カペシタビンの体内動態：トリプルプロドラッグ投与後の5-FUの腫瘍選択的分布を定量的に理解する手段としての生理学的薬物速度論モデル
薬物動態, 2001; 16(Suppl): 84-85
　 Abstract                       Full text
　 Synthesis and antifungal activities of novel 1,3-β-Image-glucan synthase inhibitors. Part 1
Bioorganic Med. Chem., 2001; 11: 395-398
　 Abstract                       Full text
　 2000年
　 COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 18)COMPARATIVE 4 AND 2 WEEKS ORAL REPEATED DOSING STUDIES ON MALE REPRODUCTIVE ORGANS IN RATS TREATED WITH 5-FLUOROURACIL
J. toxicol. Sci., 2000; 25(SI): 179-86
　 Abstract                       Full text
　 AROMATIC RETINOID RO 40-8757 REDUCES IMMUNOTOXICITIES OF CYCLOPHOSPHAMIDE AS REVEALED BY IMMUNOHISTOCHEMICAL STAINING OF LYMPHOID TISSUES AND GENERAL PATHOLOGIC EXAMINATIONS
J. toxicol. Sci., 2000; 25(3): 189-98
　 Abstract                       Full text
　 The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine
Bioorganic Med. Chem., 2000; 8: 1697-1706
　 Abstract                       Full text
　 1999年
　 Discovery and Development of Novel Anticancer Drug Capecitabine
新規抗癌剤カタペシタビンの研究開発
薬学雑誌, 1999; 119: 881-897
　 Abstract                       Full text
　 Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein
Exp. hematol., 1999; 27: 425-432
　 Abstract                       Full text
　 1998年
　 FLOW CYTOMETRIC ANALYSIS FOR SPERM VIABILITY AND COUNTS IN RATS TREATED WITH TRIMETHYLPHOSPHATE OR PYRIDOXINE
J. toxicol. Pathol., 1998; 23(1): 15-23
　 Abstract                       Full text
　 Prolonged Effect of 5-Fluorouracil and Its Derivatives on Apoptosis Induction and Mitotic Inhibition in the Intestinal Epithelium of Male DBF1 Mice
J. toxicol. Pathol., 1998; 11(3): 177-82
　 Abstract                       Full text
　 1996年
　 Report 3 : FUTURE PROSPECTS FOR TOXICOKINETICS : ITS ABILITY TO PREDICT DRUG ADVERSE EVENTS IN HUMANS (TOXICOKINETICS)
J. toxicol. Sci., 1996; 21(5): 511-6
　 Abstract                       Full text
　 COMPARATIVE IMMUNOTOXICITY ASSESSMENT OF N4-TRIMETHOXYBENZOYL-5'-DEOXY-5-FLUOROCYTIDINE (RO 09-1390) AND 5'-DEOXY-5-FLUOROURIDINE (5'-DFUR) IN BDF1 MICE
J. toxicol. Sci., 1996; 21(1): 29-39
　 Abstract                       Full text
　 1995年
　 Flow cytometric analysis for the evaluation of the rat sperm viability and number in the male reproductive toxicity studies
Congenital Anomalies, 1995; 35(2): 177-187
　 Abstract                       Full text
　 医薬品開発過程におけるトキシコキネティックスの有用性と問題点
薬物動態, 1995; 10(suppl): 174-175
　 Abstract                      Full text
　 MALE FERTILITY IN RATS TREATED WITH ETRETINATE FOR 4 WEEKS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
J. toxicol. Sci., 1995; 20(3): 281-96
　 Abstract                       Full text
　 1994年
　 1993年
　 TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
J. Toxicol. Sci., 1993; 18(4): 211-38
　 Abstract                       Full text
　 1992年
　 EFFECT OF 1, 25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
J. Toxicol. Sci., 1992; 17: 91-105
　 Abstract                       Full text
　 1990年
　 非特異的増殖性肉芽性炎症巣における脂質代謝に関する研究
岡山医学会雑誌，1990; 102(78): 949-59, 931-47
　 第1編Abstract、第2編Abstract                   第1編Full text Full text、第2編Full text
　 1987年
　 実験データの監査（<特集>監査と診断）
品質, 1987; 17(2): 44-48
　 Abstract                       Full text
　 1985年
　 Doxifluridineの毒性に関する研究, 第7報, ラットにおける26週間経口毒性試験
薬理と治療 , 1985; 13(Suppl.2): 431-68
　 Cover                       Full text
　 Doxifluridineの毒性に関する研究, 第5報, イヌにおける13週間経口毒性試験
薬理と治療 , 1985; 13(Suppl.2): 337-86
　 Cover                       Full text
　 Doxifluridineの毒性に関する研究,第4報,ラットにおける5'-DFURのFT-207および5-FUに対する5週間経口投与比較毒性試験
薬理と治療 , 1985; 13(Suppl.2): 293-335
　 Cover                       Full text
　 Doxifluridineの毒性に関する研究,第3報,ラットにおける5週間経口毒性試験
薬理と治療 , 1985; 13(Suppl.2): 259-92
　 Cover                       Full text
　 Doxifluridineの毒性に関する研究,第2報,ラットにおける13週間経口毒性試験
薬理と治療 , 1985; 13(Suppl.2): 221-58
　 Cover                       Full text
　 1983年
　 Calcitriol の毒性に関する研究(第2報) - ラットにおける5週間亜急性毒性試験 -
薬理と治療 , 1983; 11: 4189-220
　 Cover                       Full text
　 1982年
　 Etretinateの毒性に関する研究(第2報).-ラットに対する5週間経口投与亜急性毒性試験-
薬理と治療 , 1982; 10: 5045-93
　 Cover                       Full text
　 1980年
　 Procedures for renal function test in rats and their related problems: PSP excretion test and creatinine: clearance test
ラットに対する腎機能検査の実際とその問題点：PSP排泄試験，クレアチニン クリアランス試験
J. Toxicol. Sci., 1980; 5: 286-287
　 Abstract                       Full text
　 ラットに対する腎機能検査の実際とその問題点−PSP排泄試験，クレアチニン　クリアランス試験−
J. Toxicol. Sci., 1980; 5: 286-287
　 Cover                       Full text
　 1979年
　 アレルギー性炎症の病態機序：増殖性肉芽性炎症巣におおける脂質組成の変動とその意義
アレルギー, 1979; 28: 915
　 Abstract                       Full text
　 アレルギー性炎症における微小循環系の傷害機序（その1）（Chemical mediatorsおよび類似物質）
アレルギー, 1979; 28: 173-174
　 Abstract                       Full text
　 1977年
　 Quantitative analysis of serum and tissue lipid componets in experimental lavoratory animals III
J. Toxicol. Sci., 1977; 2: 73-74
　 Cover                       Full text
　 1976年
　 病的条件下における結合組織由来のbiologically active cleavage products (Chemical mediators)
アレルギー, 1976; 25(4): 369-370
　 Abstract                       Full text
　 Quantitative analysis of serum and tissue lipid componets in experimental lavoratory animals II
J. Toxicol. Sci., 1976; 1: 94-95
　 Cover                       Full text
　 Quantitative analysis of serum and tissue lipid componets in experimental lavoratory animals I
J. Toxicol. Sci., 1976; 1: 93-94
　 Cover                       Full text
　 1975年
　 Arthus 現象局所における脂質の変動
日病理会誌, 1975;
　 Abstract                       Full text